SCHEMBL25201732

SCHEMBL25201732

COc1cc2c(NCc3ccccc3)nc(N3CCCC3)nc2cc1C#CCN1CCCC1

nearest known ligand 0.62

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
EHMT2 Q96KQ7 10/20 0.62
EHMT1 Q9H9B1 6/20 0.62
KMT5A Q9NQR1 8/20 0.54
HRH4 Q9H3N8 2/20 0.48
HTR3A P46098 1/20 0.48
PDE5A O76074 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29385857 0.92 EHMT2 (0.61) EHMT2EHMT1KMT5A
SCHEMBL25204671 0.92 EHMT2 (0.61) EHMT2EHMT1KMT5A
SCHEMBL29382553 0.91 EHMT2 (0.58) EHMT2EHMT1KMT5A
SCHEMBL25224615 0.91 EHMT2 (0.58) EHMT2EHMT1KMT5A
SCHEMBL29382624 0.88 EHMT1 (0.58) EHMT2EHMT1KMT5A
SCHEMBL25220750 0.88 EHMT1 (0.58) EHMT2EHMT1KMT5A
SCHEMBL29385222 0.85 EHMT2 (0.65) EHMT2EHMT1KMT5A
SCHEMBL25201637 0.85 EHMT2 (0.65) EHMT2EHMT1KMT5A
SCHEMBL25236608 0.85 EHMT2 (0.69) EHMT2EHMT1KMT5A
SCHEMBL29385395 0.85 EHMT2 (0.69) EHMT2EHMT1KMT5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116323587-A Small molecules for autoimmune diseases and cancer treatment 阿索斯治疗公司 2023-06-23 CN disclosed
EP-4192826-A1 SMALL MOLECULES FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND CANCER Athos Therapeutics, Inc. (US) 2023-06-14 EP disclosed
US-20230159498-A1 SMALL MOLECULES FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND CANCER ATHOS THERAPEUTICS, INC. 2023-05-25 US disclosed
US-20230159498-A1 SMALL MOLECULES FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND CANCER ATHOS THERAPEUTICS, INC. 2023-05-25 US disclosed
US-20230159498-A1 SMALL MOLECULES FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND CANCER ATHOS THERAPEUTICS, INC. 2023-05-25 US disclosed
US-11485728-B2 Small molecules for the treatment of autoimmune diseases and cancer ATHOS THERAPEUTICS, INC. (US) 2022-11-01 US disclosed
US-20220073498-A1 SMALL MOLECULES FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND CANCER ATHOS THERAPEUTICS, INC. 2022-03-10 US disclosed
WO-2022031939-A1 SMALL MOLECULES FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND CANCER ATHOS THERAPEUTICS, INC. (US) 2022-02-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230159498-A1 SMALL MOLECULES FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND CANCER SSB, HLA-DRB1, UACA EHMT2 1523/4885EHMT1 1748/4885KMT5A 2696/4885
US-11485728-B2 Small molecules for the treatment of autoimmune diseases and cancer SSB, HLA-DRB1, UACA EHMT2 1523/4885EHMT1 1748/4885KMT5A 2696/4885
US-20220073498-A1 SMALL MOLECULES FOR THE TREATMENT OF AUTOIMMUNE DISEASES AND CANCER SSB, HLA-DRB1, UACA EHMT2 1523/4885EHMT1 1748/4885KMT5A 2696/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.