SCHEMBL25202080

SCHEMBL25202080

Cc1ccc(C(=O)/C=C/c2ccc(O)cc2)c(C)c1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFE2L2 Q16236 1/20 0.75
MAPT P10636 4/20 0.67
MAOA P21397 2/20 0.67
MAOB P27338 2/20 0.67
POLB P06746 1/20 0.67
RAB9A P51151 1/20 0.67
CYP3A4 P08684 2/20 0.62
CYP2C9 P11712 2/20 0.62
NFKB1 P19838 2/20 0.62
CYP2C19 P33261 2/20 0.62
CHRNA7 P36544 2/20 0.62
APP P05067 2/20 0.62
MEN1 O00255 1/20 0.62
GMNN O75496 1/20 0.62
LMNA P02545 1/20 0.62
ESR1 P03372 1/20 0.62
MMP1 P03956 1/20 0.62
GBA1 P04062 1/20 0.62
P4HB P07237 1/20 0.62
MMP2 P08253 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25191023 0.88 MAPT (0.77) MAPTMAOAMAOBPOLBRAB9A
SCHEMBL25193872 0.86 NFE2L2 (0.78) NFE2L2MAPTMAOAMAOBPOLB
SCHEMBL25196428 0.86 NFE2L2 (0.78) NFE2L2MAPTMAOAMAOBPOLB
SCHEMBL981712 0.86 NFE2L2 (1.00) NFE2L2MAPTRAB9ACYP3A4CYP2C19
SCHEMBL981711 0.86 NFE2L2 (1.00) NFE2L2MAPTRAB9ACYP3A4CYP2C19
SCHEMBL25223568 0.85 NFE2L2 (0.67) NFE2L2MAPTMAOBNFKB1MEN1
SCHEMBL25223567 0.85 NFE2L2 (0.67) NFE2L2MAPTMAOBNFKB1MEN1
SCHEMBL815315 0.84 NFE2L2 (0.70) NFE2L2CYP3A4CYP2C9CYP1A2CYP2D6
SCHEMBL25194532 0.84 NFE2L2 (0.74) NFE2L2MAOAMAOBMMP1MMP2
SCHEMBL4694196 0.84 NFE2L2 (0.69) NFE2L2MAPTMAOAMAOBRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B NFE2L2 554/4885MAPT 3297/4885MAOA 1902/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 NFE2L2 730/4885MAPT 3512/4885MAOA 3145/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 NFE2L2 730/4885MAPT 3512/4885MAOA 3145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.