SCHEMBL25210359

SCHEMBL25210359

COc1ccc(/C=C/C(=O)c2ccccc2OCC(O)COc2ccccc2C(=O)/C=C/c2ccc(OC)cc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 5/20 0.63
MAPT P10636 6/20 0.61
MAOB P27338 2/20 0.61
CYP2D6 P10635 1/20 0.61
CYP2C9 P11712 1/20 0.61
MAOA P21397 1/20 0.61
CYP2C19 P33261 1/20 0.61
CASP3 P42574 1/20 0.61
SENP8 Q96LD8 1/20 0.61
SENP7 Q9BQF6 1/20 0.61
SENP6 Q9GZR1 1/20 0.61
ABCB1 P08183 1/20 0.59
MEN1 O00255 3/20 0.58
KMT2A Q03164 3/20 0.58
NPC1 O15118 3/20 0.58
RAB9A P51151 3/20 0.58
TNFRSF1A P19438 2/20 0.57
FLT3 P36888 1/20 0.56
TUBB4A P04350 1/20 0.56
TUBB P07437 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30383512 1.00 ABCG2 (0.63) ABCG2MAPTMAOBCYP2D6CYP2C9
SCHEMBL30382495 0.89 CYP2D6 (0.54) ABCG2MAPTMAOBCYP2D6CYP2C9
SCHEMBL3440615 0.89 CYP2D6 (0.54) ABCG2MAPTMAOBCYP2D6CYP2C9
SCHEMBL25279670 0.89 CYP2D6 (0.54) ABCG2MAPTMAOBCYP2D6CYP2C9
SCHEMBL25201146 0.88 ABCB1 (0.72) ABCG2MAPTMAOBMAOACYP2C19
SCHEMBL30382699 0.88 ABCB1 (0.72) ABCG2MAPTMAOBMAOACYP2C19
SCHEMBL25191020 0.88 MAOB (0.65) ABCG2MAPTMAOBCYP2D6CYP2C9
SCHEMBL30383999 0.88 MAOB (0.65) ABCG2MAPTMAOBCYP2D6CYP2C9
SCHEMBL3440703 0.86 ABCB1 (0.51) ABCG2MAPTMAOBCYP2D6CYP2C9
SCHEMBL3440702 0.86 ABCB1 (0.51) ABCG2MAPTMAOBCYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 ABCG2 3622/4885MAPT 3512/4885MAOB 2435/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 ABCG2 3622/4885MAPT 3512/4885MAOB 2435/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.