Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 7/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.46 |
| ▸ | ELANE | P08246 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30500261 | 1.00 | ESR1 (0.46) | ESR1ESR2ELANEKDM4EALDH1A1 | |
| SCHEMBL30500214 | 0.80 | MAPT (0.60) | ESR1ESR2ELANEKDM4EALDH1A1 | |
| SCHEMBL25202713 | 0.80 | MAPT (0.60) | ESR1ESR2ELANEKDM4EALDH1A1 | |
| SCHEMBL4395617 | 0.75 | MAPT (0.61) | ELANEKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL27087469 | 0.75 | ESR2 (0.44) | ESR1ESR2KDM4EALDH1A1PTGS2 | |
| SCHEMBL29998947 | 0.75 | ESR2 (0.44) | ESR1ESR2KDM4EALDH1A1PTGS2 | |
| SCHEMBL25202116 | 0.72 | ESR2 (0.42) | ESR1ESR2KDM4EALDH1A1PTGS2 | |
| SCHEMBL30500299 | 0.72 | ESR2 (0.42) | ESR1ESR2KDM4EALDH1A1PTGS2 | |
| SCHEMBL25195367 | 0.71 | SMN1; SMN2 (0.65) | ELANEKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL30500265 | 0.71 | SMN1; SMN2 (0.65) | ELANEKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2023-09-07 | — | — | US | disclosed |
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | INIPHARM, INC. | 2023-09-07 | — | — | US | disclosed |
| EP-4185381-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | Inipharm, Inc. (US) | 2023-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230278978-A1 | THIOPHENE HSD17B13 INHIBITORS AND USES THEREOF | HSD17B3, HSD17B1, HSD17B13 | ESR1 2477/4885ESR2 1987/4885ELANE 2378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.