Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 20/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.83 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24543088 | 0.91 | GPR88 (1.00) | GPR88SLC6A4OPRK1 | |
| SCHEMBL12212380 | 0.91 | GPR88 (1.00) | GPR88 | |
| SCHEMBL2517650 | 0.91 | GPR88 (1.00) | GPR88 | |
| SCHEMBL6887373 | 0.89 | GPR88 (0.90) | GPR88 | |
| SCHEMBL12212365 | 0.88 | GPR88 (0.82) | GPR88SLC6A4OPRK1 | |
| SCHEMBL12212369 | 0.88 | GPR88 (0.78) | GPR88SLC6A4OPRK1 | |
| SCHEMBL6891711 | 0.87 | GPR88 (1.00) | GPR88 | |
| SCHEMBL2516828 | 0.87 | GPR88 (1.00) | GPR88 | |
| SCHEMBL2518159 | 0.87 | GPR88 (0.91) | GPR88SLC6A4OPRK1 | |
| SCHEMBL1666648 | 0.87 | GPR88 (0.91) | GPR88SLC6A4OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426414-B2 | Modulators of G protein-coupled receptor 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| US-8426414-B2 | Modulators of G protein-coupled receptor 88 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| US-20110251204-A1 | Modulators of G Protein-Coupled Receptor 88 | Bristol-Myers Squibb Company and Lexicon Pharmaceuticals, Inc. | 2011-10-13 | — | — | US | disclosed |
| US-20110251204-A1 | Modulators of G Protein-Coupled Receptor 88 | Bristol-Myers Squibb Company and Lexicon Pharmaceuticals, Inc. | 2011-10-13 | — | — | US | disclosed |
| US-20110251204-A1 | Modulators of G Protein-Coupled Receptor 88 | Bristol-Myers Squibb Company and Lexicon Pharmaceuticals, Inc. | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251204-A1 | Modulators of G Protein-Coupled Receptor 88 | GPR88, GPR68, GRK2 | GPR88 1/4885SLC6A4 2368/4885OPRK1 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.