Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25212749 | 1.00 | MLYCD (0.38) | MLYCDLMNAPOLBAPAF1KLKB1 | |
| SCHEMBL25267624 | 1.00 | MLYCD (0.38) | MLYCDLMNAPOLBAPAF1KLKB1 | |
| SCHEMBL25577008 | 0.84 | MLYCD (0.42) | MLYCDLMNAPOLBKDM4EGAA | |
| SCHEMBL25240747 | 0.84 | MLYCD (0.42) | MLYCDLMNAPOLBKDM4EGAA | |
| SCHEMBL25577006 | 0.84 | MLYCD (0.42) | MLYCDLMNAPOLBKDM4EGAA | |
| SCHEMBL15724389 | 0.82 | TGFBR1 (0.33) | LMNAKDM4ETRPV1TSHRGAA | |
| SCHEMBL25214379 | 0.79 | TGFBR1 (0.33) | TRPV1GAA | |
| SCHEMBL25238172 | 0.79 | TGFBR1 (0.33) | TRPV1GAA | |
| SCHEMBL25212908 | 0.79 | TGFBR1 (0.33) | TRPV1GAA | |
| SCHEMBL6886845 | 0.78 | CRACR2A (0.34) | LMNAKDM4ETRPV1TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023097234-A1 | SPIROCYCLIC MODULATORS OF CHOLESTEROL BIOSYNTHESIS AND THEIR USE FOR PROMOTING REMYELINATION | GENENTECH, INC. (US) | 2023-06-01 | — | — | WO | disclosed |