Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.71 |
| ▸ | PTPN22 | Q9Y2R2 | 5/20 | 0.64 |
| ▸ | PTPN5 | P54829 | 2/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.64 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.64 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.64 |
| ▸ | LDHA | P00338 | 1/20 | 0.57 |
| ▸ | LDHB | P07195 | 1/20 | 0.57 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.57 |
| ▸ | IGF1R | P08069 | 2/20 | 0.53 |
| ▸ | INSR | P06213 | 1/20 | 0.53 |
| ▸ | STK17B | O94768 | 4/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25270155 | 1.00 | AKT1 (0.71) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL26168407 | 0.85 | AKT1 (0.55) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL6720217 | 0.83 | AKT1 (1.00) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL31358662 | 0.83 | AKT1 (1.00) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL10921543 | 0.79 | STK17B (0.74) | AKT1IGF1RSTK17BHDAC3HDAC4 | |
| SCHEMBL25420537 | 0.78 | AKT1 (0.70) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL25248130 | 0.78 | PTPN22 (1.00) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL14444606 | 0.78 | PTPN22 (1.00) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL31358822 | 0.78 | AKT1 (0.70) | AKT1PTPN22PTPN5PTPN1PTPN7 | |
| SCHEMBL25248127 | 0.78 | PTPN22 (1.00) | AKT1PTPN22PTPN5PTPN1PTPN7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute | 2025-01-23 | — | — | US | disclosed |
| WO-2023091674-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023091674-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | Sanford Burnham Prebys Medical Discovery Institute (US) | 2023-05-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250026741-A1 | INHIBITORS OF THE ONCOGENIC SHP2 PHOSPHATASE AND USES THEREOF | PTPN18, PTPN7, PTPN1 | AKT1 194/4885PTPN22 5/4885PTPN5 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.