SCHEMBL25214837

SCHEMBL25214837

CC(=O)Nc1ccc(/C=C/C(=O)c2c(O)cccc2OCc2ccc(OC(F)(F)F)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 8/20 0.51
NFKB2 Q00653 8/20 0.51
RELA Q04206 8/20 0.51
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
GAA P10253 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
SLC5A1 P13866 1/20 0.44
SLC5A2 P31639 1/20 0.44
HDAC1 Q13547 1/20 0.43
MAOB P27338 1/20 0.42
NPC1 O15118 1/20 0.42
MAPT P10636 1/20 0.42
MAPK1 P28482 1/20 0.42
RAB9A P51151 1/20 0.42
KDM4E B2RXH2 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25195063 0.89 NFKB1 (0.56) NFKB1NFKB2RELASLC5A1SLC5A2
SCHEMBL25279027 0.88 NFKB1 (0.55) NFKB1NFKB2RELAKMT2ASLC5A1
SCHEMBL25190622 0.88 NFKB1 (0.55) NFKB1NFKB2RELAKMT2ASLC5A1
SCHEMBL25201142 0.86 NFKB1 (0.53) NFKB1NFKB2RELASLC5A1SLC5A2
SCHEMBL25200388 0.85 NFKB1 (0.62) NFKB1NFKB2RELASLC5A1SLC5A2
SCHEMBL1728539 0.79 NFKB1 (0.55) NFKB1NFKB2RELAMEN1KMT2A
SCHEMBL1725085 0.79 NFKB1 (0.55) NFKB1NFKB2RELAMEN1KMT2A
SCHEMBL25188670 0.77 NFKB1 (0.61) NFKB1NFKB2RELASLC5A1SLC5A2
SCHEMBL16150086 0.76 SLC5A1 (0.72) NFKB1NFKB2RELAMEN1KMT2A
SCHEMBL16150089 0.76 SLC5A1 (0.72) NFKB1NFKB2RELAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B NFKB1 1669/4885NFKB2 1728/4885RELA 1254/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 NFKB1 2437/4885NFKB2 2273/4885RELA 1879/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 NFKB1 2437/4885NFKB2 2273/4885RELA 1879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.