SCHEMBL25216320

SCHEMBL25216320

CC(C)(C)OC(=O)N1CCC(F)(F)C(C)(O)C1

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
HDAC2 Q92769 2/20 0.39
CYP11B2 P19099 1/20 0.39
USP30 Q70CQ3 2/20 0.38
RORC P51449 3/20 0.38
SCD5 Q86SK9 1/20 0.37
HDAC1 Q13547 1/20 0.37
HPGD P15428 1/20 0.37
EPHX2 P34913 1/20 0.37
NR1H2 P55055 1/20 0.36
ACACB O00763 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23579280 0.86 USP2 (0.44) USP2SMN1; SMN2HDAC2CYP11B2USP30
SCHEMBL25548481 0.85 NAMPT (0.33) HDAC2USP30RORC
SCHEMBL12445300 0.85 USP2 (0.46) USP2SMN1; SMN2HDAC2CYP11B2USP30
SCHEMBL1061211 0.84 USP2 (0.45) USP2SMN1; SMN2HDAC2CYP11B2USP30
SCHEMBL31343939 0.83 USP2 (0.44) USP2SMN1; SMN2HDAC2CYP11B2USP30
SCHEMBL16590451 0.82 USP2 (0.46) USP2SMN1; SMN2HDAC2CYP11B2USP30
SCHEMBL30254327 0.82 USP2 (0.46) USP2SMN1; SMN2HDAC2CYP11B2USP30
SCHEMBL25286793 0.80 USP2 (0.47) USP2SMN1; SMN2HDAC2CYP11B2USP30
SCHEMBL2218646 0.80 USP2 (0.47) USP2SMN1; SMN2HDAC2CYP11B2USP30
SCHEMBL475749 0.80 USP2 (0.47) USP2SMN1; SMN2HDAC2CYP11B2USP30

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4436571-A1 SMALL MOLECULE INHIBITORS OF KRAS MUTATED PROTEINS Merck Sharp & Dohme LLC (US) 2024-10-02 EP disclosed
CN-118302162-A Small molecule inhibitors of KRAS muteins 默沙东有限责任公司 2024-07-05 CN disclosed
WO-2023097227-A1 SMALL MOLECULE INHIBITORS OF KRAS MUTATED PROTEINS MERCK SHARP & DOHME LLC (US) 2023-06-01 WO disclosed
WO-2023097227-A1 SMALL MOLECULE INHIBITORS OF KRAS MUTATED PROTEINS MERCK SHARP & DOHME LLC (US) 2023-06-01 WO disclosed