SCHEMBL25216360

SCHEMBL25216360

O=C(O)c1ccc(C=CC(=O)c2ccccc2Br)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.70
LMNA P02545 3/20 0.70
TP53 P04637 3/20 0.70
CYP1B1 Q16678 3/20 0.55
MAPT P10636 8/20 0.53
BCHE P06276 2/20 0.53
CYP2C19 P33261 1/20 0.53
CYP2D6 P10635 1/20 0.52
MAOB P27338 5/20 0.50
CYP3A4 P08684 4/20 0.50
KMT2A Q03164 3/20 0.50
TDP1 Q9NUW8 3/20 0.50
MAOA P21397 3/20 0.50
MEN1 O00255 2/20 0.50
ALOX15 P16050 2/20 0.50
MAPK1 P28482 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
KDM4E B2RXH2 1/20 0.50
HPGD P15428 1/20 0.50
ALOX12 P18054 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25217889 1.00 ALDH1A1 (0.70) ALDH1A1LMNATP53CYP1B1MAPT
SCHEMBL10528709 0.89 MAPT (0.61) ALDH1A1LMNATP53CYP1B1MAPT
SCHEMBL29429080 0.89 ALDH1A1 (0.76) ALDH1A1LMNATP53CYP1B1MAPT
SCHEMBL14692644 0.89 ALDH1A1 (0.76) ALDH1A1LMNATP53CYP1B1MAPT
SCHEMBL10528702 0.89 MAPT (0.61) ALDH1A1LMNATP53CYP1B1MAPT
SCHEMBL14692643 0.89 ALDH1A1 (0.76) ALDH1A1LMNATP53CYP1B1MAPT
SCHEMBL16810344 0.86 ALDH1A1 (0.68) ALDH1A1LMNATP53CYP1B1MAPT
SCHEMBL25184971 0.85 MAPT (0.60) ALDH1A1LMNATP53CYP1B1MAPT
SCHEMBL12700438 0.85 MAPT (0.60) ALDH1A1LMNATP53CYP1B1MAPT
SCHEMBL30382962 0.85 MAPT (0.60) ALDH1A1LMNATP53CYP1B1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B ALDH1A1 3285/4885LMNA 1180/4885TP53 2914/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 ALDH1A1 3081/4885LMNA 1817/4885TP53 3452/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 ALDH1A1 3081/4885LMNA 1817/4885TP53 3452/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.