SCHEMBL25225683

SCHEMBL25225683

O=C(/C=C/c1ccc(OCc2ccccn2)cc1)c1ccc(N2CCC(O)CC2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CTSL P07711 2/20 0.47
▸ CTSB P07858 2/20 0.47
▸ ABCG2 Q9UNQ0 1/20 0.47
▸ MAOB P27338 5/20 0.47
▸ MAPT P10636 4/20 0.47
▸ SMN1; SMN2 Q16637 3/20 0.47
▸ NPC1 O15118 3/20 0.47
▸ RAB9A P51151 3/20 0.47
▸ ALDH1A1 P00352 2/20 0.47
▸ KMT2A Q03164 2/20 0.47
▸ L3MBTL1 Q9Y468 2/20 0.47
▸ MEN1 O00255 1/20 0.47
▸ PARP10 Q53GL7 1/20 0.47
▸ KDM4E B2RXH2 1/20 0.46
▸ KEAP1 Q14145 1/20 0.45
▸ NFE2L2 Q16236 1/20 0.45
▸ MAOA P21397 1/20 0.43
▸ HRH3 Q9Y5N1 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ HDAC3 O15379 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25210567 0.86 ABCG2 (0.65) CTSLCTSBABCG2MAOBMAPT
SCHEMBL25206148 0.86 ABCG2 (0.65) CTSLCTSBABCG2MAOBMAPT
SCHEMBL25198427 0.83 MAOB (0.51) CTSLCTSBABCG2MAOBMAPT
SCHEMBL25278953 0.82 MAOB (0.61) CTSLCTSBABCG2MAOBMAPT
SCHEMBL25199591 0.82 MAOB (0.61) CTSLCTSBABCG2MAOBMAPT
SCHEMBL25205827 0.81 ABCG2 (0.60) ABCG2MAPTSMN1; SMN2L3MBTL1KEAP1
SCHEMBL25196801 0.81 ABCG2 (0.60) ABCG2MAPTSMN1; SMN2L3MBTL1KEAP1
SCHEMBL25202010 0.79 MAOB (0.71) CTSLCTSBMAOBMAPTSMN1; SMN2
SCHEMBL25203870 0.79 MAOB (0.71) CTSLCTSBMAOBMAPTSMN1; SMN2
SCHEMBL25190665 0.78 F3 (0.64) CTSLCTSBMAOBMAPTNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 — — US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 — — US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 — — WO disclosed
EP-4429763-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS Yewsavin, Inc. (US) 2024-09-18 — — EP disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 — — US disclosed
WO-2023086388-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-05-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B CTSL 357/4885CTSB 51/4885ABCG2 1606/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 CTSL 310/4885CTSB 60/4885ABCG2 3622/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 CTSL 310/4885CTSB 60/4885ABCG2 3622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback