Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280066 | 0.77 | GAA (0.52) | GAASMN1; SMN2NPC1RAB9AMITF | |
| SCHEMBL279991 | 0.77 | GAA (0.52) | GAASMN1; SMN2NPC1RAB9AMITF | |
| SCHEMBL14395985 | 0.75 | GAA (0.50) | GAASMN1; SMN2NPC1RAB9AMITF | |
| SCHEMBL13006697 | 0.74 | GAA (0.49) | GAASMN1; SMN2NPC1RAB9AMITF | |
| SCHEMBL13385745 | 0.73 | GAA (0.66) | GAASMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL29995352 | 0.73 | SMN1; SMN2 (0.61) | GAASMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL23388826 | 0.73 | SMN1; SMN2 (0.61) | GAASMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL30397280 | 0.72 | NPC1 (0.66) | GAASMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL25233274 | 0.72 | NPC1 (0.66) | GAASMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL25202069 | 0.71 | GAA (0.56) | GAASMN1; SMN2NPC1RAB9AMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023091726-A1 | INHIBITORS OF CYCLIN‑DEPENDENT KINASE 12 (CDK12) | SYROS PHARMACEUTICALS, INC. (US) | 2023-05-25 | — | — | WO | disclosed |