Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 7/20 | 0.58 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.57 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.57 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.57 |
| ▸ | IKZF2 | Q9UKS7 | 12/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25741056 | 0.88 | IKZF2 (0.64) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL25741055 | 0.88 | IKZF2 (0.61) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL25242491 | 0.88 | IKZF1 (0.63) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL25741152 | 0.88 | CRBN (0.57) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL25741079 | 0.88 | CRBN (0.58) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL25741082 | 0.88 | CRBN (0.58) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL25242257 | 0.88 | IKZF2 (0.63) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL25741217 | 0.87 | CRBN (0.58) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL25741237 | 0.87 | CRBN (0.57) | CRBNGSPT1DDB1IKZF3IKZF2 | |
| SCHEMBL25227778 | 0.87 | CRBN (0.59) | CRBNGSPT1DDB1IKZF3IKZF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4452414-A2 | IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2024-10-30 | — | — | EP | disclosed |
| CN-118488946-A | IKAROS zinc finger family degradation agent and application thereof | 吉利德科学公司 | 2024-08-13 | — | — | CN | disclosed |
| US-20240124412-A1 | IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF | GILEAD SCIENCES, INC. | 2024-04-18 | — | — | US | disclosed |
| WO-2023122581-A2 | IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |
| WO-2023122581-A2 | IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF | GILEAD SCIENCES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240124412-A1 | IKAROS ZINC FINGER FAMILY DEGRADERS AND USES THEREOF | IKZF2, IKZF1, IKZF3 | CRBN 167/4885GSPT1 3471/4885DDB1 670/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.