Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.44 |
| ▸ | IKZF3 | Q9UKT9 | 17/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.32 |
| ▸ | TNKS | O95271 | 1/20 | 0.32 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.32 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.32 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25270702 | 0.84 | CRBN (0.38) | CRBNIKZF3PARP1TNKSPARP6 | |
| SCHEMBL30458487 | 0.82 | CRBN (0.42) | CRBNIKZF3PARP1 | |
| SCHEMBL25420904 | 0.82 | HTR2A (0.39) | CRBNIKZF3DDB1DRD2ADRA1D | |
| SCHEMBL25421495 | 0.81 | VEGFA (0.39) | CRBNIKZF3DDB1DRD2ADRA1D | |
| SCHEMBL25421297 | 0.78 | CRBN (0.36) | CRBNIKZF3DDB1PARP1PARP2 | |
| SCHEMBL25423768 | 0.78 | CRBN (0.36) | CRBNIKZF3DDB1PARP1PARP2 | |
| SCHEMBL25647408 | 0.78 | CRBN (0.62) | CRBNIKZF3DDB1DRD2ADRA1D | |
| SCHEMBL25423775 | 0.77 | HTR2C (0.39) | CRBNIKZF3DDB1PARP1PARP2 | |
| SCHEMBL25419396 | 0.77 | HTR2C (0.39) | CRBNIKZF3DDB1PARP1 | |
| SCHEMBL25231071 | 0.77 | MAPK1 (0.38) | CRBNIKZF3DDB1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104155-A1 | LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF | 标新生物医药科技(上海)有限公司 | 2023-06-15 | — | — | WO | claimed |