Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1196005 | 0.88 | MEN1 (0.51) | OPRK1GRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL1196006 | 0.88 | MEN1 (0.51) | OPRK1GRIN2BCYP2D6CYP2C9CYP3A4 | |
| Hydrochloric Acid SCHEMBL8582025 | 0.87 | MEN1 (0.50) | OPRK1GRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL1196280 | 0.82 | XIAP (0.53) | OPRK1GRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL3156202 | 0.82 | HDAC1 (0.46) | OPRK1GRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL20955401 | 0.82 | GRIN2B (0.47) | OPRK1GRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL1196281 | 0.82 | XIAP (0.53) | OPRK1GRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL25233171 | 0.81 | HDAC1 (0.48) | OPRK1GRIN2BCYP2D6CYP2C9CYP3A4 | |
| SCHEMBL29385934 | 0.80 | AVPR1A (0.39) | CYP2D6CYP2C9CYP3A4MEN1KMT2A | |
| SCHEMBL4979370 | 0.80 | MEN1 (0.46) | OPRK1GRIN2BMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. | 2023-12-28 | — | — | US | disclosed |
| EP-4192957-A2 | TRPML MODULATORS | Casma Therapeutics, Inc. (US) | 2023-06-14 | — | — | EP | disclosed |
| CN-116113698-A | TRPML modulators | 卡斯玛治疗公司 | 2023-05-12 | — | — | CN | disclosed |
| WO-2022032073-A2 | TRPML MODULATORS | CASMA THERAPEUTICS, INC. (US) | 2022-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230416262-A1 | TRPML MODULATORS | TRPM2, TRPM4, TRPM5 | OPRK1 197/4885GRIN2B 309/4885CYP2D6 2369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.