Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9288889 | 0.78 | GPR84 (0.45) | DYRK1AJAK2KEAP1NFE2L2TGFBR1 | |
| SCHEMBL10962972 | 0.76 | ADORA2A (0.43) | ADORA2AADORA1ALDH1A1CCR8DYRK1A | |
| SCHEMBL25283774 | 0.73 | ADORA2A (0.62) | ADORA2AADORA1ALDH1A1CCR8DYRK1A | |
| SCHEMBL23148088 | 0.73 | PRKCI (0.41) | ADORA2AADORA1DYRK1AJAK2TGFBR1 | |
| SCHEMBL23147654 | 0.71 | PRKCI (0.41) | ADORA2AADORA1DYRK1ATGFBR1CYP1A2 | |
| SCHEMBL29721896 | 0.71 | PRKCI (0.41) | ADORA2AADORA1DYRK1ATGFBR1CYP1A2 | |
| SCHEMBL18306004 | 0.71 | ADORA2A (0.65) | ADORA2AADORA1ALDH1A1CCR8DYRK1A | |
| SCHEMBL669933 | 0.70 | AXL (0.42) | ADORA2AADORA1ALDH1A1CCR8KMT2A | |
| SCHEMBL25888607 | 0.70 | BTK (0.34) | KEAP1NFE2L2CHEK1 | |
| SCHEMBL29721947 | 0.69 | PRKCI (0.44) | ADORA2AADORA1DYRK1ATGFBR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023119098-A1 | PROTEIN KINASE C THETA INHIBITORS | Galderma Holding SA (CH) | 2023-06-29 | — | — | WO | disclosed |
| WO-2023119098-A1 | PROTEIN KINASE C THETA INHIBITORS | Galderma Holding SA (CH) | 2023-06-29 | — | — | WO | disclosed |