Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.42 |
| ▸ | PRKCI | P41743 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10131568 | 0.79 | AURKA (0.47) | AXLPRKCIADORA2AADORA1MKNK2 | |
| SCHEMBL14697441 | 0.74 | CCR8 (0.52) | AXLPRKCIADORA2AADORA1CCR8 | |
| SCHEMBL297772 | 0.73 | CDK8 (0.55) | AXLMKNK2NUDT1MAPK1CSNK1D | |
| SCHEMBL2700901 | 0.71 | AHR (0.40) | CCR8PARP1ALDH1A1HSD17B10 | |
| SCHEMBL17844971 | 0.71 | PARP1 (0.57) | PARP1JAK2JAK3 | |
| SCHEMBL2226029 | 0.70 | ADORA2A (0.44) | AXLPRKCIADORA2AADORA1MKNK1 | |
| SCHEMBL29381263 | 0.70 | ADORA2A (0.44) | AXLPRKCIADORA2AADORA1MKNK1 | |
| SCHEMBL25237471 | 0.70 | ADORA2A (0.49) | ADORA2AADORA1CCR8KMT2AALDH1A1 | |
| SCHEMBL30826139 | 0.68 | DAO (0.41) | PARP1ALDH1A1 | |
| SCHEMBL29219201 | 0.68 | DAO (0.41) | PARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0153163-B1 | 7-SUBSTITUTED-1-CYCLOPROPYL-6,8-DIFLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACIDS; 7-SUBSTITUTED-1-CYCLOPROPYL-1,4-DIHYDRO-6-FLUORO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS; THEIR DERIVATIVES; AND A PROCESS FOR PREPARING THE COMPOUNDS | WARNER-LAMBERT COMPANY (US) | 1989-12-27 | — | — | EP | claimed |
| EP-2293778-B1 | COMPOSITION COMPRISING AN ANTIBIOTIC AND MOMETASONE | INTERVET INT BV (NL) | 2013-09-18 | — | — | EP | disclosed |
| US-20120046259-A1 | COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID | INTERVET INC. | 2012-02-23 | — | — | US | disclosed |
| EP-2293778-A2 | COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID | Intervet International B.V. (NL) | 2011-03-16 | — | — | EP | disclosed |
| US-20100087409-A1 | COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID | INTERVET INTERNATIONAL BV | 2010-04-08 | — | — | US | disclosed |
| WO-2009147144-A2 | COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID | INTERVET INTERNATIONAL B.V. (NL) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087409-A1 | COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID | CYP21A2, CYP27A1, NR3C2 | AXL 4739/4885PRKCI 3247/4885ADORA2A 1517/4885 |
| US-20120046259-A1 | COMPOSITION COMPRISING AN ANTIBIOTIC AND A CORTICOSTEROID | CYP21A2, CYP27A1, NR3C2 | AXL 4739/4885PRKCI 3247/4885ADORA2A 1517/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.