Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 11/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 7/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 3/20 | 0.39 |
| ▸ | EPM2A | O95278 | 1/20 | 0.35 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25737730 | 0.81 | AR (0.31) | PTPN1PTPN2 | |
| SCHEMBL31408042 | 0.81 | AR (0.31) | PTPN1PTPN2 | |
| SCHEMBL25232591 | 0.72 | PTPN1 (0.52) | PTPN1PTPN2PTPRCPTPN5PTPN22 | |
| SCHEMBL25737723 | 0.71 | AR (0.30) | — | |
| SCHEMBL25285623 | 0.70 | PTPN2 (0.52) | PTPN1PTPN2PTPRCEPM2APTPN22 | |
| SCHEMBL25243484 | 0.67 | PTPN5 (0.47) | PTPN1PTPN2PTPN5EPM2APTPN22 | |
| SCHEMBL27696159 | 0.66 | AR (0.47) | PTPN1PTPN2PTPRCPTPN5 | |
| SCHEMBL25279637 | 0.61 | PTPN2 (0.49) | PTPN1PTPN2PTPRCPTPN5EPM2A | |
| SCHEMBL2690335 | 0.60 | PTPN1 (1.00) | PTPN1PTPN2PTPRCPTPN5 | |
| SCHEMBL29405870 | 0.60 | PTPN1 (1.00) | PTPN1PTPN2PTPRCPTPN5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250059220-A1 | SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC (US) | 2025-02-20 | — | — | US | disclosed |
| WO-2023121939-A1 | SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC (US) | 2023-06-29 | — | — | WO | disclosed |
| WO-2023121939-A1 | SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC (US) | 2023-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250059220-A1 | SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AND METHODS OF USE THEREOF | SULT1E1, TPMT, SULT1A1 | PTPN1 1254/4885PTPN2 1539/4885PTPRC 2515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.