Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 11/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25286413 | 0.93 | TYK2 (0.44) | TYK2POLBGAAPTK2GRM5 | |
| SCHEMBL25243819 | 0.84 | TYK2 (0.66) | TYK2POLBGAA | |
| SCHEMBL25242188 | 0.83 | TYK2 (0.45) | TYK2POLBGAAGRM5PDE4A | |
| SCHEMBL25241751 | 0.83 | TYK2 (0.44) | TYK2POLBGAAPTK2PDE4A | |
| SCHEMBL25249691 | 0.80 | TYK2 (0.42) | TYK2POLBGAAGRM5PDE4A | |
| SCHEMBL25286983 | 0.80 | TYK2 (0.50) | TYK2POLBGAAPDE4AAGO2 | |
| SCHEMBL25250500 | 0.79 | TYK2 (0.52) | TYK2POLBGAA | |
| SCHEMBL25241440 | 0.77 | TYK2 (0.57) | TYK2POLBGAAPDE4AAGO2 | |
| SCHEMBL25249517 | 0.77 | TYK2 (0.50) | TYK2POLBGAAPIK3C3 | |
| SCHEMBL25242771 | 0.77 | TYK2 (0.50) | TYK2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |