Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 8/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25249498 | 0.93 | TYK2 (0.51) | TYK2POLBGAAGRM5PIK3C3 | |
| SCHEMBL25241440 | 0.85 | TYK2 (0.57) | TYK2POLBGAAPDE4AAGO2 | |
| SCHEMBL25242188 | 0.81 | TYK2 (0.45) | TYK2POLBGAAGRM5PIK3C3 | |
| SCHEMBL25241751 | 0.78 | TYK2 (0.44) | TYK2POLBGAAPIK3C3PDE4A | |
| SCHEMBL25243819 | 0.78 | TYK2 (0.66) | TYK2POLBGAAAKR1C3 | |
| SCHEMBL25249691 | 0.77 | TYK2 (0.42) | TYK2POLBGAAGRM5PIK3C3 | |
| SCHEMBL25241043 | 0.77 | TYK2 (0.34) | TYK2PIK3C3 | |
| SCHEMBL25289237 | 0.74 | GAA (0.39) | TYK2POLBGAAPIK3C3PDE4A | |
| SCHEMBL25242417 | 0.74 | POLB (0.40) | TYK2POLBGAAGRM5CYP1A2 | |
| SCHEMBL25294012 | 0.73 | POLB (0.44) | TYK2POLBGAAGRM5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |