⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiazolidinedione SCHEMBL8522420 | 0.72 | — | — | |
| Thiazolidinedione SCHEMBL4895522 | 0.71 | — | — | |
| Thiazolidinedione SCHEMBL4828229 | 0.71 | GSK3A (1.00) | — | |
| Thiazolidinedione SCHEMBL5043 | 0.71 | — | — | |
| Thiazolidinedione SCHEMBL135101 | 0.71 | — | — | |
| Thiazolidinedione SCHEMBL7844590 | 0.69 | — | — | |
| Thiazolidinedione SCHEMBL3294955 | 0.69 | — | — | |
| Thiazolidinedione SCHEMBL2331779 | 0.69 | — | — | |
| Thiazolidinedione SCHEMBL5795315 | 0.69 | — | — | |
| Thiazolidinedione SCHEMBL6789129 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018116281-A1 | PROCESS FOR PREPARING 5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY]PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE AND SALTS THEREOF | MINORYX THERAPEUTICS S.L. (ES) | 2018-06-28 | — | — | WO | disclosed |
| EP-3034075-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | Incyte Holdings Corporation (US) | 2016-06-22 | — | — | EP | disclosed |
| WO-2013056232-A2 | RXR AGONISTS COMPOUNDS AND METHODS | CASE WESTERN RESERVE UNIVERSITY (US) | 2013-04-18 | — | — | WO | disclosed |
| US-8357701-B2 | Galactokinase inhibitors | UNIVERSITY OF MIAMI (US) | 2013-01-22 | — | — | US | disclosed |
| US-20110251236-A1 | GALACTOKINASE INHIBITORS | UNIVERSITY OF MIAMI (US) | 2011-10-13 | — | — | US | disclosed |
| WO-2009023773-A9 | GALACTOKINASE INHIBITORS | UNIV MIAMI (US) | 2009-07-30 | — | — | WO | disclosed |
| WO-2009023773-A2 | GALACTOKINASE INHIBITORS | UNIVERSITY OF MIAMI (US) | 2009-02-19 | — | — | WO | disclosed |
| WO-2008070230-A2 | METHODS AND COMPOSITIONS FOR TREATING CENTRAL NERVOS SYSTEM TUMORS | CASE WESTERN RESERVE UNIVERSITY (US) | 2008-06-12 | — | — | WO | disclosed |
| WO-2008064157-A1 | IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-05-29 | — | — | WO | disclosed |