Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 3/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25252907 | 1.00 | JAK2 (0.38) | JAK2JAK3RETBTKCSNK2A2 | |
| SCHEMBL29418549 | 0.86 | RET (0.48) | JAK2JAK3RETBTKCSNK2A2 | |
| SCHEMBL30599741 | 0.86 | RET (0.48) | JAK2JAK3RETBTKCSNK2A2 | |
| SCHEMBL25253013 | 0.78 | ATR (0.43) | BTKUSP30ATRPRKDCPPARA | |
| SCHEMBL25213424 | 0.78 | ATR (0.43) | BTKUSP30ATRPRKDCPPARA | |
| SCHEMBL25253014 | 0.78 | ATR (0.43) | BTKUSP30ATRPRKDCPPARA | |
| SCHEMBL25270046 | 0.75 | RET (0.41) | JAK2JAK3RETCSNK2A2CSNK2B | |
| SCHEMBL25267849 | 0.75 | ATR (0.40) | BTKUSP30ATRROCK2ROCK1 | |
| SCHEMBL25215421 | 0.75 | ATR (0.40) | BTKUSP30ATRROCK2ROCK1 | |
| SCHEMBL25267669 | 0.74 | ROCK2 (0.40) | JAK2JAK3BTKATRROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4192587-A1 | BTK INHIBITORS | Biogen MA Inc. (US) | 2023-06-14 | — | — | EP | disclosed |