Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2532121 | 0.98 | CES2 (0.47) | CES2MEN1FAAHMAPK1KMT2A | |
| SCHEMBL2523983 | 0.98 | CES2 (0.47) | CES2MEN1FAAHMAPK1KMT2A | |
| SCHEMBL2530546 | 0.94 | CA1 (0.45) | CA1CES2LTA4HSMN1; SMN2MEN1 | |
| SCHEMBL2527248 | 0.90 | SMN1; SMN2 (0.41) | CES2LTA4HSMN1; SMN2MEN1FAAH | |
| SCHEMBL2530049 | 0.88 | KDM4E (0.44) | CES2SMN1; SMN2MEN1FAAHMAPK1 | |
| SCHEMBL2528159 | 0.88 | KDM4E (0.44) | CES2SMN1; SMN2MEN1FAAHMAPK1 | |
| SCHEMBL31472637 | 0.88 | CES2 (0.57) | CA1CES2MEN1FAAHMAPK1 | |
| SCHEMBL2527280 | 0.88 | CA1 (0.47) | CA1CES2LTA4HMAPK1 | |
| SCHEMBL28441934 | 0.88 | CES2 (0.57) | CA1CES2MEN1FAAHMAPK1 | |
| SCHEMBL25429127 | 0.88 | LTA4H (0.50) | CA1CES2LTA4HSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461135-B2 | Boron-containing small molecules as anti-inflammatory agents | ANACOR PHARMACEUTICALS, INC. (US) | 2013-06-11 | — | — | US | claimed |
| US-8039450-B2 | Boron-containing small molecules as anti-inflammatory agents | ANACOR PHARMACEUTICALS, INC. (US) | 2011-10-18 | — | — | US | claimed |