Sugi Predict

Sugi Predict / Compounds / SCHEMBL25254420

SCHEMBL25254420

SCHEMBL25254420

Brc1ccc2c3c(cccc13)OC2

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 0.37
▸ HSD17B10 Q99714 2/20 0.37
▸ CYP1A2 P05177 2/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ HPGD P15428 2/20 0.37
▸ TYMS P04818 1/20 0.37
▸ CYP2C19 P33261 1/20 0.37
▸ MAPT P10636 2/20 0.36
▸ CASP1 P29466 1/20 0.36
▸ CASP7 P55210 1/20 0.36
▸ CYP1B1 Q16678 8/20 0.35
▸ LMNA P02545 2/20 0.34
▸ NPC1 O15118 1/20 0.34
▸ RAB9A P51151 1/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ PNMT P11086 1/20 0.33
▸ KMT2A Q03164 2/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ GAA P10253 1/20 0.32
▸ MAOA P21397 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5090657 0.81 HSP90AA1 (0.42) KDM4EHSD17B10CYP1A2ALDH1A1HPGD
SCHEMBL29756067 0.78 MAPT (0.47) KDM4EHSD17B10CYP1A2ALDH1A1HPGD
SCHEMBL25837908 0.78 TYMS (0.44) KDM4EHSD17B10CYP1A2ALDH1A1HPGD
SCHEMBL30101372 0.74 ALDH1A1 (0.57) KDM4EHSD17B10CYP1A2ALDH1A1HPGD
SCHEMBL2198474 0.74 ALDH1A1 (0.57) KDM4EHSD17B10CYP1A2ALDH1A1HPGD
SCHEMBL14373225 0.71 HSD17B10 (0.59) KDM4EHSD17B10CYP1A2ALDH1A1HPGD
SCHEMBL5092242 0.71 ALDH1A1 (0.39) KDM4EHSD17B10CYP1A2ALDH1A1HPGD
SCHEMBL13725598 0.71 ALDH1A1 (0.48) KDM4EHSD17B10CYP1A2ALDH1A1HPGD
SCHEMBL30366558 0.70 CYP1A2 (0.45) CYP1A2ALDH1A1MAPTCYP1B1KMT2A
SCHEMBL19417358 0.70 CYP1A2 (0.45) CYP1A2ALDH1A1MAPTCYP1B1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250059196-A1 TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) 2025-02-20 — — US disclosed
EP-4458819-A1 TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF Shanghai Hansoh Biomedical Co., Ltd. (CN) 2024-11-06 — — EP disclosed
WO-2023125877-A1 TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 上海翰森生物医药科技有限公司 2023-07-06 — — WO disclosed
WO-2023125877-A1 TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 上海翰森生物医药科技有限公司 2023-07-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250059196-A1 TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF WEE1, CYP51A1, WEE2 KDM4E 2363/4885HSD17B10 752/4885CYP1A2 336/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.