Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30563419 | 1.00 | GRM5 (0.56) | GRM5KDM4ELMNAHTTNPC1 | |
| SCHEMBL31139929 | 0.85 | KDM4E (0.42) | GRM5KDM4ELMNAHTTNPC1 | |
| SCHEMBL30563509 | 0.84 | ALDH1A1 (0.49) | GRM5NPC1RAB9A | |
| SCHEMBL25234058 | 0.84 | ALDH1A1 (0.49) | GRM5NPC1RAB9A | |
| SCHEMBL3649040 | 0.82 | FFAR1 (0.53) | GRM5KDM4ENPC1RAB9APOLB | |
| SCHEMBL17213607 | 0.80 | KDM4E (0.50) | GRM5KDM4EHTTNPC1RAB9A | |
| SCHEMBL25846553 | 0.79 | RXFP1 (0.51) | GRM5KDM4ELMNAHTTNPC1 | |
| SCHEMBL3713749 | 0.76 | ACACB (0.52) | GRM5 | |
| SCHEMBL30006746 | 0.76 | CA1 (0.46) | KDM4ELMNAHTTNPC1RAB9A | |
| SCHEMBL3416767 | 0.76 | PTGDR2 (0.50) | GRM5KDM4EHTTPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11905306-B2 | Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of SARS virus | SOUTHERN RESEARCH INSTITUTE (US) | 2024-02-20 | — | — | US | disclosed |
| WO-2023122212-A2 | SUBSTITUTED PHENYL ETHYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS | SOUTHERN RESEARCH INSTITUTE (US) | 2023-06-29 | — | — | WO | disclosed |
| WO-2023122212-A2 | SUBSTITUTED PHENYL ETHYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS | SOUTHERN RESEARCH INSTITUTE (US) | 2023-06-29 | — | — | WO | disclosed |
| US-20230192733-A1 | SUBSTITUTED PHENYL ET458HYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS | SOUTHERN RESEARCH INSTITUTE | 2023-06-22 | — | — | US | disclosed |
| US-20230192733-A1 | SUBSTITUTED PHENYL ET458HYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS | SOUTHERN RESEARCH INSTITUTE | 2023-06-22 | — | — | US | disclosed |
| US-20230192733-A1 | SUBSTITUTED PHENYL ET458HYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS | SOUTHERN RESEARCH INSTITUTE | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192733-A1 | SUBSTITUTED PHENYL ET458HYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS | SARS1, ACE2, ACE | GRM5 233/4885KDM4E 100/4885LMNA 3223/4885 |
| US-11905306-B2 | Substituted phenyl ethynyl pyridine carboxamides as potent inhibitors of SARS virus | SARS1, ACE2, TMPRSS2 | GRM5 602/4885KDM4E 176/4885LMNA 3265/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.