SCHEMBL25257938

SCHEMBL25257938

Cc1cc(Br)c(F)cc1C=CC(C)(C)[S+](N)[O-]

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 2/20 0.36
KDM1B Q8NB78 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30578935 0.78
SCHEMBL30014389 0.77
SCHEMBL30682749 0.70 PTGS2 (0.39)
SCHEMBL30576676 0.70
SCHEMBL25254004 0.69 KDM1A (0.33) KDM1AKDM1B
SCHEMBL30484117 0.69 KDM1A (0.33) KDM1AKDM1B
SCHEMBL30567472 0.68 AR (0.37)
SCHEMBL30512199 0.66 NFE2L2 (0.43)
SCHEMBL18479925 0.65 KDM1A (0.37) KDM1AKDM1B
SCHEMBL30014359 0.65

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4480482-A2 PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE AbbVie Inc. (US) 2024-12-25 EP disclosed
WO-2023125907-A1 DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE BEIGENE, LTD. (KY) 2023-07-06 WO disclosed