Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.57 |
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.57 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.53 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.53 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.53 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.53 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.53 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.53 |
| ▸ | GALR3 | O60755 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL180003 | 0.92 | CHRM5 (0.65) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL15954 | 0.92 | CHRM5 (0.65) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL30183040 | 0.92 | CHRM5 (0.65) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL28569529 | 0.91 | TSHR (0.58) | CHRM5CHRM1CHRM3ALDH1A1CHRM2 | |
| Hydrochloric Acid SCHEMBL9492830 | 0.90 | CHRM5 (0.63) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Iodide SCHEMBL723953 | 0.90 | CHRM5 (0.63) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Bromide SCHEMBL366432 | 0.90 | CHRM1 (0.63) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Ammonia Solution, Strong SCHEMBL468696 | 0.90 | CHRM5 (0.63) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL31575073 | 0.90 | CHRM5 (0.63) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL29649178 | 0.90 | CHRM5 (0.63) | CHRM5CHRM1CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11826470-B2 | Preparation of solid dosage forms comprising antibodies by solution/suspension layering | TILLOTTS PHARMA AG (CH) | 2023-11-28 | — | — | US | claimed |
| CN-113150622-A | Photocatalyst coating with heat preservation performance and preparation method thereof | 董峰 | 2021-07-23 | — | — | CN | claimed |
| CN-113072390-A | Porous ceramic heating body and preparation method thereof | 上海梦泺企业管理咨询有限公司 | 2021-07-06 | — | — | CN | claimed |
| CN-110343441-B | Water-based negative ion coating and preparation method thereof | 炫杰复合材料（上海）有限公司 | 2021-03-26 | — | — | CN | claimed |
| US-10293046-B2 | Compositions and methods for reducing overdose | INTELLIPHARMACEUTICS CORP. (CA) | 2019-05-21 | — | — | US | claimed |
| US-8465777-B2 | Diffusion-controlled dosage form and method of fabrication including three dimensional printing | THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2013-06-18 | — | — | US | claimed |
| US-20120177696-A1 | Diffusion-controlled dosage form and method of fabrication including three dimensional printing | THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-07-12 | — | — | US | claimed |
| US-8088415-B2 | Core-and-shell dosage form or unit in which the core contains API and in which the shell substantially governs the release such as by controlling diffusion of API through the shell. The shell may comprise a release-blocking polymer, and particles | THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2012-01-03 | — | — | US | claimed |
| EP-1421932-B1 | Polyacrylic film forming compositions | MCNEIL PPC INC (US) | 2010-09-22 | — | — | EP | claimed |
| EP-1503741-B1 | DIFFUSION-CONTROLLED DOSAGE FORM AND METHOD OF FABRICATION INCLUDING THREE DIMENSIONAL PRINTING | MASSACHUSETTS INST TECHNOLOGY (US) | 2008-09-10 | — | — | EP | claimed |
| EP-1503741-A2 | DIFFUSION-CONTROLLED DOSAGE FORM AND METHOD OF FABRICATION INCLUDING THREE DIMENSIONAL PRINTING | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2005-02-09 | — | — | EP | claimed |
| EP-1421932-A1 | Polyacrylic film forming compositions | McNEIL-PPC, INC. (US) | 2004-05-26 | — | — | EP | claimed |
| US-20040022755-A1 | Polyacrylic film forming compositions | JOHNSON & JOHNSON CONSUMER INC. | 2004-02-05 | — | — | US | claimed |
| US-20040005360-A1 | Diffusion-controlled dosage form and method of fabrication including three dimensional printing | THERICS, INC. | 2004-01-08 | — | — | US | claimed |
| WO-2003092633-A2 | DIFFUSION-CONTROLLED DOSAGE FORM AND METHOD OF FABRICATION INCLUDING THREE DIMENSIONAL PRINTING | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2003-11-13 | — | — | WO | claimed |
| US-6156340-A | Orally administrable time release drug containing products | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2000-12-05 | — | — | US | claimed |
| CN-115464135-B | Injection molding feed with modified stainless steel powder and cationic binder | 合肥工业大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-115464135-A | Injection molding feed with modified stainless steel powder and cationic binder | 合肥工业大学 | 2022-12-13 | — | — | CN | disclosed |
| US-6156340-A | Orally administrable time release drug containing products | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2000-12-05 | — | — | US | disclosed |
| US-4439322-A | IONIC COPOLYMER | TORAY INDUSTRIES, INC. (JP) | 1984-03-27 | — | — | US | disclosed |