Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LTC4S | Q16873 | 1/20 | 0.39 |
| ▸ | POLQ | O75417 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | PRKX | P51817 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25259349 | 0.85 | TACR1 (0.47) | SLC6A4SLC6A2SLC6A3HTR2ARORC | |
| SCHEMBL30700163 | 0.78 | MGLL (0.42) | SLC6A4SLC6A2SLC6A3HTR2ARORC | |
| SCHEMBL30700687 | 0.78 | MCHR1 (0.43) | SLC6A4SLC6A2SLC6A3HTR2ARORC | |
| SCHEMBL22462908 | 0.78 | MGLL (0.56) | SLC6A4SLC6A2SLC6A3HTR2AIDO1 | |
| SCHEMBL25296154 | 0.77 | SLC6A4 (0.56) | SLC6A4SLC6A2SLC6A3HTR2APOLQ | |
| SCHEMBL21722779 | 0.77 | IDO1 (0.39) | SLC6A4SLC6A2SLC6A3IDO1S1PR1 | |
| SCHEMBL19411886 | 0.77 | IDO1 (0.48) | SLC6A4IDO1S1PR1PRKXIKBKE | |
| SCHEMBL25254744 | 0.77 | SLC6A4 (0.41) | SLC6A4SLC6A2SLC6A3HTR2ARORC | |
| SCHEMBL22462869 | 0.76 | SLC6A4 (0.38) | SLC6A4SLC6A2SLC6A3RORCIDO1 | |
| SCHEMBL30700165 | 0.75 | MCHR1 (0.41) | SLC6A4SLC6A2SLC6A3HTR2ARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11981661-B2 | Heterocyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 2024-05-14 | — | — | US | disclosed |
| EP-4208456-A1 | HETEROCYCLIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2023-07-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11981661-B2 | Heterocyclic compounds | CBR3, BRIX1, CCNY | SLC6A4 4365/4885SLC6A2 4620/4885SLC6A3 4359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.