Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 3/20 | 0.41 |
| ▸ | RXRA | P19793 | 3/20 | 0.40 |
| ▸ | RXRB | P28702 | 2/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25226413 | 0.92 | KCNA3 (0.39) | KCNA3MCHR1KDM4EALDH1A1HPGD | |
| SCHEMBL26182090 | 0.91 | KCNA3 (0.37) | KCNA3RXRARXRBRXRGNR4A2 | |
| SCHEMBL25275975 | 0.91 | KCNA3 (0.38) | KCNA3RXRARXRBRXRGNR4A2 | |
| SCHEMBL25229541 | 0.89 | KCNA3 (0.42) | KCNA3RXRARXRBRXRGNR4A2 | |
| SCHEMBL25271829 | 0.85 | KCNA3 (0.38) | KCNA3RXRARXRBRXRGNR4A2 | |
| SCHEMBL25227213 | 0.85 | KCNA3 (0.43) | KCNA3KDM4EALDH1A1HPGDGLA | |
| SCHEMBL25277964 | 0.84 | KCNA3 (0.38) | KCNA3KDM4EALDH1A1HPGDCYP1A2 | |
| SCHEMBL25227266 | 0.84 | KCNA3 (0.38) | KCNA3KDM4EALDH1A1HPGDGLA | |
| SCHEMBL25281739 | 0.84 | KCNA3 (0.39) | KCNA3RXRARXRBRXRGNR4A2 | |
| SCHEMBL25280942 | 0.84 | GPBAR1 (0.42) | KCNA3KDM4EALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066377-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-02-27 | — | — | US | disclosed |
| WO-2023114539-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114539-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066377-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | POLRMT, TFAM, POLM | KCNA3 4324/4885RXRA 1185/4885RXRB 1215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.