Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.31 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25276303 | 1.00 | KCNA3 (0.38) | KCNA3KMT2AALDH1A1HPGDMYC | |
| SCHEMBL30440359 | 0.91 | KCNA3 (0.35) | KCNA3KMT2AALDH1A1HPGDMYC | |
| SCHEMBL25272915 | 0.91 | KCNA3 (0.35) | KCNA3KMT2AALDH1A1HPGDMYC | |
| SCHEMBL25271729 | 0.89 | KCNA3 (0.42) | KCNA3KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL25271730 | 0.89 | KCNA3 (0.42) | KCNA3KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL25274722 | 0.89 | ALDH2 (0.38) | KCNA3KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL25274723 | 0.89 | ALDH2 (0.38) | KCNA3KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL25279274 | 0.83 | KCNA3 (0.38) | KCNA3ALDH1A1HPGDMYCKDM4E | |
| SCHEMBL25229393 | 0.82 | KCNA3 (0.39) | KCNA3KMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL30440719 | 0.82 | KCNA3 (0.39) | KCNA3KMT2AALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066377-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-02-27 | — | — | US | disclosed |
| WO-2023114539-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114539-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066377-A1 | AMINO CHROMEN-2-ONE MODULATORS OF POLRMT | POLRMT, TFAM, POLM | KCNA3 4324/4885KMT2A 307/4885ALDH1A1 3192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.