Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.37 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19154127 | 0.81 | ERN1 (0.53) | ERN1BRD4GRM2LRRK2ACVR1 | |
| SCHEMBL17794805 | 0.78 | BRD4 (0.43) | ERN1BRD4LRRK2CLK2ALOX5AP | |
| SCHEMBL17794960 | 0.77 | BRD4 (0.43) | BRD4GRM2LRRK2CLK2ALOX5AP | |
| SCHEMBL612984 | 0.76 | BRD4 (0.53) | ERN1BRD4GRM2ALOX5APFEN1 | |
| SCHEMBL16278740 | 0.76 | ERN1 (0.48) | ERN1BRD4GRM2LRRK2CREBBP | |
| SCHEMBL14895629 | 0.76 | ERN1 (0.66) | ERN1ACVR1PIK3CDPIK3CAPIK3CB | |
| SCHEMBL31048522 | 0.75 | FGFR3 (0.53) | ERN1BRD4GRM2LRRK2ACVR1 | |
| SCHEMBL31048691 | 0.74 | ERN1 (0.47) | ERN1GRM2CCNCCDK8 | |
| SCHEMBL17806620 | 0.74 | ALOX5AP (0.41) | BRD4LRRK2CLK2ALOX5APFEN1 | |
| SCHEMBL14840407 | 0.74 | CCNC (0.57) | ERN1BRD4CCNCCDK8AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192667-A1 | BETA-LACTAM DERIVATIVES FOR THE TREATMENT OF DISEASES | INSILICO MEDICINE IP LIMITED (HK) | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192667-A1 | BETA-LACTAM DERIVATIVES FOR THE TREATMENT OF DISEASES | QPCT, QPCTL, BCAT1 | ERN1 3711/4885BRD4 1268/4885GRM2 1861/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.