Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.54 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.54 |
| ▸ | CHRNA5 | P30532 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30466113 | 1.00 | CHRNB2 (0.54) | CHRNB2CHRNA4CHRNA7CHRNA5NPC1 | |
| SCHEMBL25694060 | 0.86 | CHRNB2 (0.49) | CHRNB2CHRNA4CHRNA7CHRNA5NPC1 | |
| SCHEMBL23629606 | 0.73 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA7CHRNA5NPC1 | |
| SCHEMBL25235927 | 0.71 | CHRNB2 (0.53) | CHRNB2CHRNA4CHRNA7CHRNA5NPC1 | |
| SCHEMBL18588003 | 0.70 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA7CHRNA5NPC1 | |
| SCHEMBL18588004 | 0.70 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA7CHRNA5NPC1 | |
| SCHEMBL19615663 | 0.70 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA7CHRNA5NPC1 | |
| SCHEMBL18587701 | 0.70 | CHRNB2 (0.52) | CHRNB2CHRNA4CHRNA7CHRNA5NPC1 | |
| SCHEMBL30959853 | 0.70 | CHRNB2 (0.63) | CHRNB2CHRNA4CHRNA7CHRNA5NPC1 | |
| SCHEMBL25895867 | 0.70 | CHRNB2 (0.63) | CHRNB2CHRNA4CHRNA7CHRNA5NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023114200-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS AND INTERMEDIATES THEREOF | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |