Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 7/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | LTK | P29376 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25241751 | 0.83 | TYK2 (0.44) | GAAKDM4EALDH1A1MAPTTYK2 | |
| SCHEMBL25242188 | 0.81 | TYK2 (0.45) | GAAMAPTTYK2POLBPIK3C3 | |
| SCHEMBL25282403 | 0.79 | GRM5 (0.43) | GAAMAPTTYK2POLBAKR1C3 | |
| SCHEMBL25249498 | 0.76 | TYK2 (0.51) | GAATYK2POLBPIK3C3PDE4A | |
| SCHEMBL25249691 | 0.76 | TYK2 (0.42) | GAAMAPTTYK2POLBPIK3C3 | |
| SCHEMBL25286413 | 0.74 | TYK2 (0.44) | GAAKDM4EALDH1A1MAPTTYK2 | |
| SCHEMBL25285692 | 0.74 | TYK2 (0.59) | GAATYK2POLBJAK2TNNI3K | |
| SCHEMBL25240979 | 0.73 | TYK2 (0.43) | GAATYK2POLBAKR1C3CDK9 | |
| SCHEMBL25242417 | 0.72 | POLB (0.40) | GAAMAPTTYK2POLBAKR1C3 | |
| SCHEMBL31247671 | 0.71 | GRM5 (0.54) | GAAKDM4EALDH1A1TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |