⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19586624 | 0.74 | MAPK1 (0.40) | — | |
| SCHEMBL23663106 | 0.71 | TSHR (0.35) | — | |
| SCHEMBL31284269 | 0.70 | DUT (0.33) | — | |
| SCHEMBL2830017 | 0.69 | HRH2 (0.44) | — | |
| SCHEMBL22412589 | 0.68 | KDM4E (0.40) | — | |
| SCHEMBL13682952 | 0.67 | — | — | |
| SCHEMBL16416137 | 0.67 | MAPT (0.32) | — | |
| SCHEMBL18282757 | 0.66 | DYRK1A (0.33) | — | |
| SCHEMBL19635131 | 0.66 | MAPT (0.34) | — | |
| SCHEMBL17094646 | 0.65 | BACE1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691989-B2 | Macrocyclic indoles as Mcl-1 inhibitors | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2023-07-04 | — | — | US | disclosed |
| US-20220340595-A1 | MACROCYCLIC INDOLES AS MCL-1 INHIBITORS | ASCENTAGE PHARMA (SUZHOU) CO., LTD. (CN) | 2022-10-27 | — | — | US | disclosed |
| CN-110845520-B | Macrocyclic indoles as MCL-1 inhibitors | 苏州亚盛药业有限公司 | 2021-04-13 | — | — | CN | disclosed |
| CN-110845520-A | Macrocyclic indoles as MCL-1 inhibitors | 苏州亚盛药业有限公司 | 2020-02-28 | — | — | CN | disclosed |