SCHEMBL2529181

SCHEMBL2529181

CS(=O)(=O)O.O=C(O)C1CCCc2ccccc21

nearest known ligand 0.51

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAOB known ✓ P27338 1/20 0.47
LMNA P02545 1/20 0.51
HTT P42858 2/20 0.50
CYP1A2 P05177 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.48
RAB9A P51151 1/20 0.48
MEN1 O00255 1/20 0.48
KMT2A Q03164 1/20 0.48
MAOA P21397 1/20 0.47
TAS1R3 Q7RTX0 1/20 0.46
TAS1R1 Q7RTX1 1/20 0.46
TAS1R2 Q8TE23 1/20 0.46
ALDH1A1 P00352 3/20 0.46
CYP2D6 P10635 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
EPHX1 P07099 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2796237 0.91 HTT (0.54) HTTCYP1A2SMN1; SMN2RAB9AMEN1
SCHEMBL29608780 0.91 HTT (0.54) HTTCYP1A2SMN1; SMN2RAB9AMEN1
SCHEMBL29484110 0.91 HTT (0.54) HTTCYP1A2SMN1; SMN2RAB9AMEN1
SCHEMBL2792830 0.91 HTT (0.54) HTTCYP1A2SMN1; SMN2RAB9AMEN1
SCHEMBL242244 0.91 HTT (0.54) HTTCYP1A2SMN1; SMN2RAB9AMEN1
SCHEMBL29706163 0.91 HTT (0.54) HTTCYP1A2SMN1; SMN2RAB9AMEN1
Hydrochloric Acid SCHEMBL8944136 0.89 HTT (0.53) HTTCYP1A2SMN1; SMN2RAB9AMEN1
Hydrochloric Acid SCHEMBL2999173 0.89 HTT (0.53) HTTCYP1A2SMN1; SMN2RAB9AMEN1
SCHEMBL1844342 0.85 HTT (0.49) HTTCYP1A2SMN1; SMN2RAB9AMEN1
Ethylenediamine SCHEMBL10773019 0.83 HTT (0.48) HTTSMN1; SMN2MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110250238-A1 SYSTEM FOR THE COLON DELIVERY OF DRUGS SUBJECT TO ENZYME DEGRADATION AND/OR POORLY ABSORBED IN THE GASTROINTESTINAL TRACT SANGALLI MARIA EDVIGE 2011-10-13 US disclosed
EP-1965828-A2 PHARMACEUTICAL FORMULATION FOR INCREASED EPITHELIAL PERMEABILITY OF GLUCOSE-REGULATING PEPTIDE Nastech Pharmaceutical Company Inc. (US) 2008-09-10 EP disclosed
WO-2007146448-A1 PHARMACEUTICAL FORMULATIONS OF GLP-1 DERIVATIVES NASTECH PHARMACEUTICAL COMPANY INC. (US) 2007-12-21 WO disclosed
WO-2007065156-A2 PHARMACEUTICAL FORMULATION FOR INCREASED EPITHELIAL PERMEABILITY OF GLUCOSE-REGULATING PEPTIDE NASTECH PHARMACEUTICAL COMPANY INC. (US) 2007-06-07 WO disclosed