SCHEMBL25296201

SCHEMBL25296201

C#Cc1ccc(-c2nnc(NC3CCCN(C)C3)c(C3CC3)c2C2CC2)c(O)c1

nearest known ligand 0.60

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 12/20 0.60
IL1B P01584 10/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25257249 1.00 NLRP3 (0.60) NLRP3IL1B
SCHEMBL30488547 0.96 NLRP3 (0.58) NLRP3IL1B
SCHEMBL30488523 0.96 NLRP3 (0.58) NLRP3IL1B
SCHEMBL29030484 0.96 NLRP3 (0.58) NLRP3IL1B
SCHEMBL29030490 0.96 NLRP3 (0.58) NLRP3IL1B
SCHEMBL31091185 0.91 NLRP3 (0.60) NLRP3IL1B
SCHEMBL31091212 0.86 NLRP3 (0.79) NLRP3IL1B
SCHEMBL31091189 0.86 NLRP3 (0.69) NLRP3IL1B
SCHEMBL25256054 0.85 NLRP3 (0.62) NLRP3IL1B
SCHEMBL25297240 0.85 NLRP3 (0.62) NLRP3IL1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250152584-A1 NLRP3 INFLAMMASOME INHIBITOR AND USES THEREOF TRANSTHERA SCIENCES (NANJING), INC. (CN) 2025-05-15 US disclosed
EP-4461729-A1 ANTIGEN BINDING PROTEIN TARGETING MSLN AND USE THEREOF Transthera Sciences (Nanjing), Inc. (CN) 2024-11-13 EP disclosed
WO-2023131277-A1 NLRP3 INFLAMMASOME INHIBITOR AND USES THEREOF 药捷安康(南京)科技股份有限公司 2023-07-13 WO disclosed
WO-2023131277-A1 NLRP3 INFLAMMASOME INHIBITOR AND USES THEREOF 药捷安康(南京)科技股份有限公司 2023-07-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250152584-A1 NLRP3 INFLAMMASOME INHIBITOR AND USES THEREOF NLRP3, NLRP1, PYCARD NLRP3 1/4885IL1B 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.