Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 11/20 | 0.48 |
| ▸ | TYMS | P04818 | 2/20 | 0.44 |
| ▸ | FPGS | Q05932 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25301066 | 1.00 | DHFR (0.48) | DHFRTYMSFPGS | |
| SCHEMBL24344221 | 0.93 | DHFR (0.40) | DHFR | |
| SCHEMBL25171613 | 0.91 | DHFR (0.48) | DHFRTYMSFPGS | |
| SCHEMBL25171614 | 0.91 | DHFR (0.48) | DHFRTYMSFPGS | |
| SCHEMBL25298843 | 0.89 | DHFR (0.46) | DHFRFPGS | |
| SCHEMBL25251194 | 0.89 | DHFR (0.46) | DHFRFPGS | |
| SCHEMBL25725435 | 0.84 | DHFR (0.40) | DHFR | |
| SCHEMBL30400568 | 0.84 | DHFR (0.40) | DHFR | |
| SCHEMBL31476915 | 0.84 | DHFR (0.56) | DHFRTYMS | |
| SCHEMBL24343802 | 0.82 | TDP1 (0.40) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023126297-A1 | ANTIFOLATE LINKER-DRUGS AND ANTIBODY-DRUG CONJUGATES | BYONDIS B.V. (NL) | 2023-07-06 | — | — | WO | disclosed |