Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 20/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | RAMP1 | O60894 | 1/20 | 0.41 |
| ▸ | CALCA | P06881 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12219383 | 0.87 | CALCRL (0.56) | CALCRLKCNH2RAMP1CALCA | |
| SCHEMBL12219388 | 0.85 | CALCRL (0.54) | CALCRLKCNH2RAMP1CALCA | |
| SCHEMBL2527632 | 0.85 | CALCRL (0.54) | CALCRLKCNH2RAMP1CALCA | |
| SCHEMBL2530687 | 0.85 | CALCRL (0.54) | CALCRLKCNH2RAMP1CALCA | |
| SCHEMBL2528473 | 0.85 | CALCRL (0.54) | CALCRLKCNH2RAMP1CALCA | |
| SCHEMBL2530738 | 0.85 | CALCRL (0.54) | CALCRLKCNH2RAMP1CALCA | |
| SCHEMBL2530265 | 0.85 | CALCRL (0.54) | CALCRLKCNH2RAMP1CALCA | |
| SCHEMBL2526598 | 0.83 | CALCRL (0.61) | CALCRLKCNH2 | |
| SCHEMBL2527824 | 0.83 | CALCRL (0.52) | CALCRLKCNH2RAMP1CALCA | |
| SCHEMBL4700066 | 0.82 | CALCRL (0.46) | CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8993588-B2 | Carboxamide heterocyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2015-03-31 | — | — | US | disclosed |
| US-8039460-B2 | CGRP (Calcitonin Gene-Related Peptide); migraine and cluster headache; compounds based on 6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepine or 6,7,8,9-tetrahydro-5H-imidazo[1,2-a]azepine | MERCK SHARP & DOHME CORP. (US) | 2011-10-18 | — | — | US | disclosed |
| US-20100179166-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME LLC | 2010-07-15 | — | — | US | disclosed |
| EP-1796678-B1 | CARBOXAMIDE SPIROLACTAM CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2010-04-14 | — | — | EP | disclosed |
| EP-1802637-B1 | CGRP RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2008-10-15 | — | — | EP | disclosed |
| US-7390798-B2 | Carboxamide spirolactam CGRP receptor antagonists | MERCK & CO., INC. (US) | 2008-06-24 | — | — | US | disclosed |
| US-20080113966-A1 | Cgrp Receptor Antagonists | MERCK SHARP & DOHME LLC | 2008-05-15 | — | — | US | disclosed |
| US-20070293470-A1 | Carboxamide Spirolactam Cgrp Receptor Antagonists | MERCK SHARP & DOHME LLC | 2007-12-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293470-A1 | Carboxamide Spirolactam Cgrp Receptor Antagonists | BDKRB1, CALCRL, BDKRB2 | CALCRL 2/4885KCNH2 66/4885RAMP1 27/4885 |
| US-20080113966-A1 | Cgrp Receptor Antagonists | BDKRB1, BDKRB2, CCKBR | CALCRL 4/4885KCNH2 332/4885RAMP1 116/4885 |
| US-20100179166-A1 | CARBOXAMIDE HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | BDKRB1, BDKRB2, CCKBR | CALCRL 6/4885KCNH2 346/4885RAMP1 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.