Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 7/20 | 0.60 |
| ▸ | CYP11B1 | P15538 | 6/20 | 0.60 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.60 |
| ▸ | CYP17A1 | P05093 | 4/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.56 |
| ▸ | GSK3B | P49841 | 3/20 | 0.56 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | AKT2 | P31751 | 1/20 | 0.56 |
| ▸ | FLT4 | P35916 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | CLK2 | P49760 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30381358 | 1.00 | CYP11B2 (0.60) | CYP11B2CYP11B1CYP19A1CYP17A1DYRK1A | |
| SCHEMBL14244706 | 0.94 | CYP11B2 (0.65) | CYP11B2CYP11B1CYP19A1CYP17A1DYRK1A | |
| SCHEMBL26260221 | 0.82 | CYP11B2 (0.85) | CYP11B2CYP11B1CYP19A1CYP17A1DYRK1A | |
| SCHEMBL15507438 | 0.81 | CYP2A6 (0.62) | CYP11B2CYP11B1CYP19A1CYP17A1DYRK1A | |
| SCHEMBL26260198 | 0.80 | CYP11B2 (0.88) | CYP11B2CYP11B1CYP19A1CYP17A1MKNK2 | |
| SCHEMBL13304740 | 0.78 | CYP11B2 (0.71) | CYP11B2CYP11B1CYP19A1CYP17A1MKNK2 | |
| SCHEMBL30269889 | 0.78 | PIK3C3 (0.64) | CYP11B2CYP11B1CYP19A1CYP17A1DYRK1A | |
| SCHEMBL31349414 | 0.78 | PIK3C3 (0.64) | CYP11B2CYP11B1CYP19A1CYP17A1DYRK1A | |
| SCHEMBL783005 | 0.78 | PIK3C3 (0.64) | CYP11B2CYP11B1CYP19A1CYP17A1DYRK1A | |
| SCHEMBL2823299 | 0.77 | DYRK1A (0.73) | CYP11B2CYP11B1CYP19A1CYP17A1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066349-A1 | CYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2025-02-27 | — | — | US | disclosed |
| EP-4444420-A2 | CYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | Prothena Biosciences Limited (IE) | 2024-10-16 | — | — | EP | disclosed |
| WO-2023107723-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066349-A1 | CYCLIC COMPOUNDS AND THEIR USE FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | DYRK2, DYRK1A, PYGB | CYP11B2 1093/4885CYP11B1 1089/4885CYP19A1 2479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.