Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27185413 | 0.84 | TSHR (0.47) | TSHRNPSR1KDM5AKDM5BTP53 | |
| Bromide SCHEMBL9951827 | 0.81 | TBXAS1 (0.37) | TSHRNPSR1KDM4EALDH1A1MAPT | |
| SCHEMBL28930016 | 0.81 | TSHR (0.45) | TSHRNPSR1KDM5AKDM5BTP53 | |
| SCHEMBL6386138 | 0.80 | TSHR (0.47) | TSHRNPSR1TP53KDM4EALDH1A1 | |
| SCHEMBL6386142 | 0.80 | TSHR (0.47) | TSHRNPSR1TP53KDM4EALDH1A1 | |
| SCHEMBL30884166 | 0.78 | TSHR (0.47) | TSHRNPSR1KDM5AKDM5BTP53 | |
| SCHEMBL6387533 | 0.78 | TSHR (0.45) | TSHRNPSR1TP53ALDH1A1MAPT | |
| SCHEMBL6387535 | 0.78 | TSHR (0.45) | TSHRNPSR1TP53ALDH1A1MAPT | |
| SCHEMBL28671837 | 0.77 | TSHR (0.46) | TSHRNPSR1KDM5AKDM5BTP53 | |
| SCHEMBL7664873 | 0.76 | TSHR (0.54) | SRCTSHRNPSR1TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023117954-A1 | PROCESS FOR REMOVING MAKEUP FROM KERATIN FIBRES WHICH HAVE BEEN TREATED BEFOREHAND WITH A COMPOSITION COMPRISING A PHOTOCROSSLINKABLE POLYMER | L'OREAL (FR) | 2023-06-29 | — | — | WO | disclosed |