Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.48 |
| ▸ | TIPARP | Q7Z3E1 | 10/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25309986 | 0.95 | PARP1 (0.48) | PARP1TIPARPMAPTPKMSMN1; SMN2 | |
| SCHEMBL25309586 | 0.86 | PARP1 (0.46) | PARP1TIPARPMAPTPKMSMN1; SMN2 | |
| SCHEMBL25309608 | 0.85 | PARP1 (0.44) | PARP1TIPARPMAPTPKMSMN1; SMN2 | |
| SCHEMBL25307526 | 0.85 | PARP1 (0.42) | PARP1TIPARP | |
| SCHEMBL25309578 | 0.85 | SPR (0.43) | PARP1MAPTPKMSMN1; SMN2 | |
| SCHEMBL25309030 | 0.84 | TIPARP (0.63) | PARP1TIPARP | |
| SCHEMBL25308646 | 0.83 | PARP1 (0.42) | PARP1TIPARPSMN1; SMN2 | |
| SCHEMBL25309989 | 0.83 | PARP1 (0.46) | PARP1TIPARPMAPTSMN1; SMN2 | |
| SCHEMBL25311716 | 0.83 | PARP1 (0.42) | PARP1TIPARPSMN1; SMN2 | |
| SCHEMBL30510760 | 0.83 | PARP1 (0.44) | PARP1TIPARPMAPTPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |