Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 16/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 6/20 | 0.45 |
| ▸ | SPR | P35270 | 1/20 | 0.43 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.40 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30510764 | 1.00 | CHRM1 (0.49) | CHRM1PARP1PARP2SPRTNK1 | |
| SCHEMBL25310262 | 0.90 | PARP1 (0.44) | CHRM1PARP1PARP2TNKS | |
| SCHEMBL30510773 | 0.87 | HTR1A (0.43) | CHRM1PARP1TNKS | |
| SCHEMBL25307141 | 0.87 | HTR1A (0.43) | CHRM1PARP1TNKS | |
| SCHEMBL25309923 | 0.85 | PARP1 (0.41) | CHRM1PARP1PARP2TIPARPTNKS | |
| SCHEMBL30510762 | 0.85 | PARP1 (0.41) | CHRM1PARP1PARP2TIPARPTNKS | |
| SCHEMBL25309578 | 0.85 | SPR (0.43) | PARP1PARP2SPRTNKS | |
| SCHEMBL25310532 | 0.84 | PARP1 (0.62) | PARP1PARP2TIPARPTNKS | |
| SCHEMBL25308646 | 0.80 | PARP1 (0.42) | PARP1PARP2TIPARPTNKS | |
| SCHEMBL25307526 | 0.80 | PARP1 (0.42) | PARP1PARP2TIPARPTNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |