Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25310041 | 0.83 | TSHR (0.67) | POLBTSHRLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL19902371 | 0.79 | TSHR (0.54) | POLBTSHRLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL13721278 | 0.78 | POLB (1.00) | POLBTSHRLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL26123997 | 0.76 | POLB (0.42) | POLBTSHRLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL29480990 | 0.75 | POLB (0.68) | POLBTSHRLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL1786764 | 0.75 | POLB (0.68) | POLBTSHRLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL9530036 | 0.74 | POLB (0.67) | POLBTSHRLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL13265509 | 0.73 | POLB (0.65) | POLBTSHRLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL13720699 | 0.72 | TSHR (1.00) | POLBTSHRLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL17354960 | 0.72 | TSHR (0.56) | POLBTSHRLMNASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |