Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25310697 | 0.83 | POLB (0.63) | TSHRALDH1A1SMN1; SMN2POLBKDM4E | |
| SCHEMBL13720699 | 0.81 | TSHR (1.00) | TSHRALDH1A1SMN1; SMN2POLBKDM4E | |
| SCHEMBL26120490 | 0.79 | TSHR (0.47) | TSHRALDH1A1SMN1; SMN2POLBKDM4E | |
| SCHEMBL25310305 | 0.77 | ALDH1A1 (0.76) | TSHRALDH1A1SMN1; SMN2POLBKDM4E | |
| SCHEMBL19902371 | 0.77 | TSHR (0.54) | TSHRALDH1A1SMN1; SMN2POLBNPSR1 | |
| SCHEMBL9202473 | 0.75 | TSHR (0.70) | TSHRALDH1A1SMN1; SMN2POLBKDM4E | |
| SCHEMBL25309821 | 0.74 | SMN1; SMN2 (0.70) | TSHRALDH1A1SMN1; SMN2POLBKDM4E | |
| SCHEMBL5010738 | 0.74 | SMN1; SMN2 (1.00) | TSHRALDH1A1SMN1; SMN2POLBKDM4E | |
| SCHEMBL29069352 | 0.71 | ALDH1A1 (0.52) | TSHRALDH1A1SMN1; SMN2POLBKDM4E | |
| SCHEMBL13720557 | 0.71 | POLB (1.00) | TSHRALDH1A1SMN1; SMN2POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |