Sugi Predict

Sugi Predict / Compounds / SCHEMBL25311574

SCHEMBL25311574

SCHEMBL25311574

Cc1n[nH]c(=O)c2cc(Br)c(=O)n(C)c12

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPK1 P28482 2/20 0.33
▸ S1PR2 O95136 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ L3MBTL1 Q9Y468 1/20 0.33
▸ PIK3CA P42336 8/20 0.33
▸ PIK3R1 P27986 6/20 0.33
▸ AURKA O14965 1/20 0.33
▸ KDR P35968 1/20 0.33
▸ AURKB Q96GD4 1/20 0.33
▸ NPC1 O15118 1/20 0.32
▸ RAB9A P51151 1/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ ALDH1A1 P00352 1/20 0.32
▸ GLA P06280 1/20 0.32
▸ GAA P10253 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ HTT P42858 1/20 0.32
▸ HSD17B10 Q99714 1/20 0.32
▸ RXFP1 Q9HBX9 1/20 0.32
▸ ATM Q13315 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30526339 0.73 SOS1 (0.38) —
SCHEMBL30526331 0.73 SOS1 (0.39) —
SCHEMBL25263114 0.72 PRMT5 (0.36) AURKAKDRAURKBKDM4EALDH1A1
SCHEMBL30067059 0.72 KDM4E (0.33) MAPK1PIK3CAKDM4EALDH1A1GLA
SCHEMBL25307594 0.72 KDM4E (0.33) MAPK1PIK3CAKDM4EALDH1A1GLA
SCHEMBL30066967 0.72 PIK3CA (0.33) MAPK1PIK3CAKDM4EALDH1A1GLA
SCHEMBL25309589 0.72 PDE1B (0.39) PIK3CAPRMT5WDR77
Hydrochloric Acid SCHEMBL25307453 0.72 SOS1 (0.38) —
Hydrochloric Acid SCHEMBL25261129 0.72 SOS1 (0.39) —
SCHEMBL23122437 0.67 ALDH1A1 (0.41) MAPK1ALDH1A1HPGDHTTPDPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250154147-A1 NOVEL AMINE-SUBSTITUTED PHTHALAZINES AND DERIVATIVES AS SOS1 INHIBITORS U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL TRUSTEE 2025-05-15 — — US disclosed
EP-4463454-A1 NOVEL AMINE-SUBSTITUTED PHTHALAZINES AND DERIVATIVES AS SOS1 INHIBITORS Jazz Pharmaceuticals Ireland Limited (IE) 2024-11-20 — — EP disclosed
WO-2023135260-A1 NOVEL AMINE-SUBSTITUTED PHTHALAZINES AND DERIVATIVES AS SOS1 INHIBITORS JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) 2023-07-20 — — WO disclosed
WO-2023135260-A1 NOVEL AMINE-SUBSTITUTED PHTHALAZINES AND DERIVATIVES AS SOS1 INHIBITORS JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) 2023-07-20 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250154147-A1 NOVEL AMINE-SUBSTITUTED PHTHALAZINES AND DERIVATIVES AS SOS1 INHIBITORS SOS1, SOS2, SOST MAPK1 121/4885S1PR2 2810/4885TP53 592/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.