Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA known ✓ | P35790 | 10/20 | 0.37 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2529292 | 0.83 | NPC1 (0.45) | MEN1MAPTKMT2ACHKABCHE | |
| Bromide SCHEMBL2530194 | 0.83 | CYP19A1 (0.44) | MEN1MAPTKMT2ACHKABCHE | |
| Bromide SCHEMBL1046638 | 0.83 | MEN1 (0.50) | MEN1MAPTKMT2ACHKAACHE | |
| SCHEMBL10326004 | 0.83 | MAPT (0.47) | MEN1MAPTKMT2ACHKA | |
| SCHEMBL21841998 | 0.81 | CHKA (0.47) | MEN1MAPTKMT2ACHKABCHE | |
| Hydrochloric Acid SCHEMBL2533086 | 0.81 | CYP2A6 (0.46) | MEN1MAPTKMT2ACHKA | |
| Bromide SCHEMBL2532404 | 0.78 | MEN1 (0.44) | MEN1MAPTKMT2ACHKA | |
| SCHEMBL12576093 | 0.78 | MEN1 (0.38) | MEN1MAPTKMT2ACHKABCHE | |
| Bromide SCHEMBL2534726 | 0.77 | MEN1 (0.61) | MEN1MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL2530334 | 0.76 | CYP19A1 (0.43) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8632914-B2 | Triazolium and imidazolium salts and uses thereof | UNIVERSITY HEALTH NETWORK (CA) | 2014-01-21 | — | — | US | disclosed |
| US-20110257235-A1 | TRIAZOLIUM AND IMIDAZOLIUM SALTS AND USES THEREOF | UNIVERSITY HEALTH NETWORK (CA) | 2011-10-20 | — | — | US | disclosed |
| WO-2010025558-A1 | TRIAZOLIUM AND IMIDAZOLIUM SALTS AND USES THEREOF AS ANTIMALARIALS | UNIVERSITY HAEALTH NETWORK (CA) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257235-A1 | TRIAZOLIUM AND IMIDAZOLIUM SALTS AND USES THEREOF | ARG2, ARG1, CIT | CHKA 1469/4885ACHE 2517/4885MEN1 3327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.