SCHEMBL25314522

SCHEMBL25314522

O=C(c1cccc(-c2nc3ccccc3[nH]2)n1)N1CC2CN(C(=O)c3ccc4ccccc4n3)CC2C1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LANCL2 Q9NS86 1/20 0.70
RAB9A P51151 4/20 0.51
SMN1; SMN2 Q16637 3/20 0.51
TSHR P16473 2/20 0.51
ALDH1A1 P00352 2/20 0.51
NPC1 O15118 2/20 0.51
PKM P14618 2/20 0.51
HPGD P15428 2/20 0.51
KDM4E B2RXH2 2/20 0.51
TP53 P04637 1/20 0.51
ALOX15 P16050 1/20 0.51
HSD17B10 Q99714 1/20 0.51
HRH4 Q9H3N8 2/20 0.49
HCRTR1 O43613 1/20 0.42
HCRTR2 O43614 1/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
GAA P10253 2/20 0.42
MAPK1 P28482 1/20 0.42
PDE10A Q9Y233 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25311738 0.93 LANCL2 (0.80) LANCL2RAB9ASMN1; SMN2TSHRALDH1A1
SCHEMBL29063389 0.93 LANCL2 (0.80) LANCL2RAB9ASMN1; SMN2TSHRALDH1A1
SCHEMBL29466328 0.93 LANCL2 (0.80) LANCL2RAB9ASMN1; SMN2TSHRALDH1A1
SCHEMBL25310879 0.87 LANCL2 (0.61) LANCL2RAB9ASMN1; SMN2TSHRALDH1A1
SCHEMBL25313429 0.87 LANCL2 (0.73) LANCL2RAB9ASMN1; SMN2TSHRALDH1A1
SCHEMBL29466320 0.87 LANCL2 (0.73) LANCL2RAB9ASMN1; SMN2TSHRALDH1A1
Hydrochloric Acid SCHEMBL25311498 0.86 LANCL2 (0.71) LANCL2RAB9ASMN1; SMN2TSHRALDH1A1
Hydrochloric Acid SCHEMBL29466273 0.86 LANCL2 (0.71) LANCL2RAB9ASMN1; SMN2TSHRALDH1A1
SCHEMBL25262280 0.83 LANCL2 (0.64) LANCL2RAB9ASMN1; SMN2ALDH1A1NPC1
SCHEMBL25312836 0.83 LANCL2 (0.64) LANCL2RAB9ASMN1; SMN2ALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240101552-A1 CARBONYL HETEROCYCLIC COMPOUND AND APPLICATION THEREOF SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) 2024-03-28 US disclosed
EP-4215526-A1 CARBONYL HETEROCYCLIC COMPOUND AND APPLICATION THEREOF Shanghai Pharmaceuticals Holding Co., Ltd. (CN) 2023-07-26 EP disclosed
EP-4215526-A1 CARBONYL HETEROCYCLIC COMPOUND AND APPLICATION THEREOF Shanghai Pharmaceuticals Holding Co., Ltd. (CN) 2023-07-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240101552-A1 CARBONYL HETEROCYCLIC COMPOUND AND APPLICATION THEREOF LANCL2, CBS, LCP2 LANCL2 1/4885RAB9A 2591/4885SMN1; SMN2 3536/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.