Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.31 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.30 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.30 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2528446 | 0.88 | ALDH1A1 (0.39) | PDK2AOC3MEN1KMT2AAURKA | |
| SCHEMBL2528492 | 0.86 | MEN1 (0.32) | AAK1MMP13PDK2MEN1KMT2A | |
| SCHEMBL2531098 | 0.84 | NPSR1 (0.40) | MMP13PDK2AOC3MEN1KMT2A | |
| SCHEMBL2526963 | 0.84 | MEN1 (0.46) | MMP13PDK2AOC3MEN1KMT2A | |
| SCHEMBL2528461 | 0.83 | EGFR (0.34) | MMP13PDK2AOC3MEN1KMT2A | |
| SCHEMBL2530483 | 0.83 | MMP13 (0.33) | MMP13PDK2AOC3MEN1KMT2A | |
| SCHEMBL2529738 | 0.82 | EGFR (0.36) | MMP13PDK2AOC3MEN1KMT2A | |
| SCHEMBL2532853 | 0.82 | AURKA (0.34) | MMP13PDK2AOC3MEN1KMT2A | |
| SCHEMBL2528887 | 0.82 | MEN1 (0.34) | AAK1MMP13PDK2AOC3MEN1 | |
| SCHEMBL2528203 | 0.82 | AOC3 (0.34) | MMP13PDK2AOC3KAT6AKAT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039501-B2 | Synephrine derivatives useful as anti-inflammatory agents | UNIVERSITEIT GENT (BE) | 2011-10-18 | — | — | US | disclosed |
| US-20090029999-A1 | Synephrine derivatives useful as anti-inflammatory agents | UNIVERSITEIT GENT (BE) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090029999-A1 | Synephrine derivatives useful as anti-inflammatory agents | HRH1, HRH3, HRH2 | AAK1 2130/4885MMP13 231/4885PDK2 934/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.