Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 9/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.47 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.44 |
| ▸ | IL2 | P60568 | 2/20 | 0.44 |
| ▸ | SGK1 | O00141 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL721560 | 0.90 | MAP3K11 (0.71) | MAP3K11KITLRRK2MAP4K1IL2 | |
| SCHEMBL2527600 | 0.81 | MAP3K11 (0.73) | MAP3K11KITLRRK2 | |
| SCHEMBL7172012 | 0.78 | MAP3K11 (0.53) | MAP3K11KITMAPK14LTA4HTLR7 | |
| SCHEMBL10164830 | 0.77 | MAP3K11 (0.51) | MAP3K11KITLRRK2MAP4K1IL2 | |
| SCHEMBL2526092 | 0.76 | MAP3K11 (0.60) | MAP3K11KITLRRK2IGF1RCYP3A4 | |
| SCHEMBL722011 | 0.74 | KIT (0.56) | MAP3K11KITLRRK2MAP4K1IL2 | |
| SCHEMBL12763551 | 0.73 | KIT (0.61) | KITMAP4K1IL2 | |
| SCHEMBL7905848 | 0.72 | KIT (0.60) | KITMAP4K1IL2 | |
| SCHEMBL2981587 | 0.72 | PRKCQ (0.78) | — | |
| SCHEMBL721043 | 0.72 | MAP3K11 (1.00) | MAP3K11LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379561-A2 | MLK INHIBITORS AND METHODS OF USE | University Of Rochester (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010068483-A2 | MLK INHIBITORS AND METHODS OF USE | UNIVERSITY OF ROCHESTER (US) | 2010-06-17 | — | — | WO | disclosed |