Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.53 |
| ▸ | LTA4H | P09960 | 3/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7096353 | 0.90 | LTA4H (0.62) | LTA4HDRD3DRD2EHMT2EHMT1 | |
| SCHEMBL7100163 | 0.89 | LTA4H (0.61) | LTA4HDRD3DRD2EHMT2EHMT1 | |
| SCHEMBL7095054 | 0.86 | SYK (0.53) | MAP3K11LTA4HDRD3DRD2KIT | |
| SCHEMBL8661974 | 0.81 | EHMT2 (0.48) | LTA4HDRD3DRD2MAPK14EHMT2 | |
| SCHEMBL2531824 | 0.78 | MAP3K11 (0.56) | MAP3K11LTA4HKITMAPK14TLR7 | |
| SCHEMBL11817599 | 0.76 | KDM4E (0.58) | LTA4HKDM4EGAA | |
| SCHEMBL1748737 | 0.76 | TLR8 (0.60) | LTA4HRETMAPK14TLR7EHMT2 | |
| SCHEMBL3436048 | 0.76 | POLB (0.55) | LTA4HDRD3DRD2HTR1AKDM4E | |
| SCHEMBL17429741 | 0.76 | PDE3B (0.50) | RETTLR7KDM4E | |
| SCHEMBL1544861 | 0.76 | TLR8 (0.48) | MAP3K11RETMAPK14TLR7EHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309551-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014273-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-02-21 | — | — | WO | disclosed |